Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a).This mark has been reported to associate with silent genes.Here, we use a cell model of neural differentiation, which upon PRMT6 knockout exhibits proliferation and differentiation defects.Strikingly, we detect PRMT6-depen
In field archaeology, the importance of non-diagnostic sherds is often overlooked.This archaeological experiment suggests that archaeologists should take into greater consideration, contexts where sherds are found grouped together in close proximity.The authors tested a series of experimental drops of modern pots which were treated as substitutions
IntroductionWe have demonstrated that intensive cognitive training can produce sustained improvements in cognitive performance in adolescents.Few studies, however, have investigated the neural basis of these training effects, leaving the underlying mechanism of cognitive plasticity during this period unexplained.MethodsIn this study, we trained 51
OBJECTIVES/SPECIFIC AIMS: To identify the most frequently reported barriers/constraints and resources by junior faculty in achieving their goals at a large medical school in the Western United States.METHODS/STUDY POPULATION: We reviewed 222 individual development plans (IDPs) from 26 departments in an academic medical center for content regarding